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Research We Fund: Extramural Discovery Science

Mission Boost Grants (MBG)

Grant Overview

Mission Boost Grants (MBG) are designed to support research projects that specifically focus on the translation to human testing. MBGs are opportunities for independent investigators at all levels to seek additional, or "boost," resources for innovative, clinical-enabling projects.

MBGs offer 2 stages of funding:

  • Stage I requires the investigator to develop outcome-specific, unequivocal milestones that reduce the risks of studying a new drug, device, or procedure in patients.  
  • Stage II supports testing in cancer patients.

Eligibility

Stage I Mission Boost

We no longer require MBG applicants to be current or former ACS grantees or fellows, you ARE eligible to submit a proposal if you:

  • Work at a US academic institution or eligible non-profit 
  • Are an independent investigator with a full-time faculty appointment (or equivalent). Applicants may be at any career stage.

Stage II Mission Boost

You ARE eligible to submit a proposal if you:

  • Work at a US academic institution or eligible non-profit 
  • Are an independent investigator with a full-time faculty appointment or (equivalent). Applicants may be at any career stage.
  • Previously held or currently hold a Stage I Mission Boost Grant for a minimum of 18 months AND have completed Stage I milestones


Grant Term and Budget

Stage I Mission Boost 

Stage I will be for a term of up to two years in duration with an allowable budget of $135,000 per year direct costs plus 10% allowable indirect costs ($297,000 allowable total costs).

Stage II Mission Boost

Stage II will be for a term of up to 18 months with an allowable budget up to $545,000 direct costs plus 10% allowable indirect costs.

Application Deadlines

June 1, 2025 and December 1, 2025

Want to see some recently published studies from grantees?

Go to Research Highlights.