Can Vaginal Cancer Be Prevented?

Infection with human papillomavirus (HPV) is a risk factor for vaginal cancer. HPV infections occur mainly in younger women and are less common in women over 30. The reason for this is not clear.

HPV passes from one person to another during skin-to-skin contact with an infected area of the body. HPV can be spread during sexual activity – including vaginal, anal, and oral sex – but sex doesn’t have to occur for the infection to spread. All that's needed is skin-to-skin contact with a part of the body infected with HPV. The virus can be spread through genital-to-genital contact. It’s even possible for an infection to spread through hand-to-genital contact.

An HPV infection also seems to be able to be spread from one part of the body to another. This means that an infection may start in the cervix and then spread to the vagina and vulva.

HPV is very common, so having sex with even one other person can put you at risk. In most cases, the body is able to clear the infection on its own. But sometimes, the infection doesn't go away and becomes chronic. Over time, chronic infection, especially with high-risk HPV types, can cause certain cancers, including vaginal cancer and pre-cancer.

HPV vaccines

There are vaccines that protect against infection with certain types of HPV. These vaccines can only be used to prevent HPV infection – they don't help treat an existing infection. To work best, the vaccines should be given before a person is exposed to HPV (such as through sexual activity). These vaccines are approved to help prevent vaginal cancers and pre-cancers. They are also approved to help prevent other cancers, as well as anal and genital warts.

For more information about HPV and HPV vaccines, see HPV (Human Papillomavirus).

Condom use

Condoms (“rubbers”) provide some protection against HPV. Condoms cannot protect completely because they don’t cover every possible HPV-infected area of the body, such as skin on the genital or anal area. Still, condoms do provide some protection against HPV, and protect against HIV and some other sexually transmitted diseases.

Don’t smoke

Not smoking is another way to lower vaginal cancer risk. People who don’t smoke are also less likely to develop a number of other cancers, such as those of the lungs, mouth, throat, bladder, kidneys, and several other organs.

Find and treat pre-cancers

Most vaginal squamous cell cancers are believed to start out as pre-cancerous changes, called vaginal intraepithelial neoplasia or VAIN. VAIN may be present for years before turning into a true (invasive) cancer.

Screening for cervical cancer (such as with a Pap test and HPV tests) can sometimes pick up these pre-cancers or problems that might lead to them forming. If a pre-cancer is found, it can be treated, stopping cancer before it really starts.