Supportive Therapy for the Person with Chronic Myelomonocytic Leukemia (CMML)

Supportive therapy is treatment aimed at preventing or relieving symptoms. The main purpose of this type of treatment is to improve the comfort and quality of life for someone diagnosed with cancer, no matter what type of cancer the person has or what the goal of treatment might be. You might also hear supportive care referred to as palliative care, symptom management, or comfort care.

Treating chronic myelomonocytic leukemia (CMML) can often help with the symptoms it causes. But some treatments are aimed more at the symptoms themselves.

 

Treatments to help with low blood cell counts

For many people with CMML, one of the main goals of treatment is to prevent the problems caused by low blood cell counts.

For instance, low red blood cell counts (anemia) can cause severe fatigue. Treating the anemia with blood transfusions and/or growth factors such as epoetin alfa can often help patients feel better and allow them to be more active.

Some people are concerned about a slight risk of infection (hepatitis or HIV) spread by blood transfusion. This possibility is very unlikely because all donated blood is tested before being transfused, and the benefits of the transfused cells greatly outweigh this very small risk.

People with CMML often need a lot of blood transfusions. This can cause excess iron to build up in the body. This extra iron can deposit in the liver and heart, affecting how well the organs work. This iron build up is usually seen only in people who receive many transfusions over a period of years. Drugs called chelating agents can be used to treat and prevent iron overload from transfusions. Chelating agents are substances that bind with iron so that the body can get rid of it. They can be given intravenously (IV) or as an injection (shot) under the skin.

CMML patients with bleeding problems caused by a shortage of platelets may benefit from platelet transfusions.

People with CMML tend to get infections very easily. They should be especially careful to avoid cuts and scrapes and care for any injury right away. They should tell their doctors about any fever, signs of pneumonia (cough, shortness of breath), urinary infection (burning when urinating), or other signs of infection right away. Doctors will treat any known or suspected infections with antibiotics. See Infections in People with Cancer for more details.