This annual report provides the estimated numbers of new cancer cases and deaths in 2013 as well as current cancer incidence, mortality, and survival statistics and information on cancer symptoms, risk factors, early detection, and treatment. About 1,660,290 new cancer cases are expected to be diagnosed in 2013, and in 2013 about 580,350 Americans are projected to die of cancer, almost 1,600 people a day. Cancer remains the second most common cause of death in the US, accounting for nearly 1 of every 4 deaths. (Please note: The projected numbers of new cancer cases and deaths in 2013 should not be compared with previous years to track cancer trends because they are model-based and vary from year to year for reasons other than changes in cancer occurrence. Age-standardized incidence and death rates should be used to measure cancer trends.)