Staging of Distal Bile Duct Cancers

If you are diagnosed with distal bile duct cancer, your doctors will try to figure out if it has spread, and if so, how far. This process is called staging. The stage of a cancer describes how much cancer is in the body. It helps determine how extensive the cancer is and how best to treat it. Doctors also use a cancer's stage when talking about survival statistics.

The earliest stage for distal bile duct cancers is stage 0, also called carcinoma in situ (CIS). Stages then range from stage I (1) through stage IV (4). As a rule, the lower the number, the less the cancer has spread. A higher number, such as stage IV, means the cancer has spread more. Within each numbered stage, an earlier letter (A, B) means a lower stage.

Although each person’s cancer experience is unique, cancers with similar stages tend to have a similar outlook and are often treated in much the same way.

How is the stage determined?

The staging system most often used for distal bile duct cancer is the American Joint Committee on Cancer (AJCC) TNM system. This system based on 3 key pieces of information:

• The extent (size) of the main tumor (T): Has the cancer grown through the wall of the bile duct? Has the cancer reached nearby structures or organs?
• The spread to nearby lymph nodes (N): Has the cancer spread to nearby lymph nodes?
• The spread (metastasis) to distant sites (M): Has the cancer spread to distant lymph nodes or distant organs such as the bones, lungs, or peritoneum (the lining of the abdomen)?

The system described below is the most recent AJCC system. It's used only for distal bile duct cancers, which are bile duct cancers that start along the common bile duct. Staging systems for cancers starting in other parts of the bile ducts are described in:

• Intrahepatic Bile Duct Cancer Stages (for cancers starting in bile ducts within the liver)
• Perihilar (Hilar) Bile Duct Cancer Stages (for cancers starting in the hilum, just outside the liver)

Numbers or letters after T, N, and M provide more details about each of these factors. Higher numbers mean the cancer is more advanced.

Once a person’s T, N, and M categories have been determined, this information is combined in a process called stage grouping to assign an overall stage. For more on this, see Cancer Staging.

Distal bile duct cancer is typically given a clinical stage based on the results of a physical exam, biopsy, and imaging tests (described in Tests for Bile Duct Cancer). If surgery is done, the pathologic stage (also called the surgical stage) is determined by examining the tissue removed during the operation.

Cancer staging can be complex, so ask your doctor to explain it to you in a way you understand.

Stages of distal bile duct cancer

AJCC Stage	Stage grouping	Stage description*
0	Tis         N0 M0	The cancer is only in the mucosa (the innermost layer of cells in the bile duct). It hasn't started growing into the deeper layers (Tis).   It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
I	T1       N0 M0	The cancer has grown less than 5 mm into the bile duct wall (T1).   It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
IIA	T2       N0 M0	The cancer has grown between 5 mm and 12 mm into the bile duct wall (T2).   It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
OR
T1 N1   M0	The cancer has grown less than 5 mm into the bile duct wall (T1) and has spread to 1 to 3 nearby lymph nodes (N1).   It has not spread to distant sites (M0).
IIB	T3       N0 M0	The cancer has grown more than 12 mm into the bile duct wall (T3).   It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
OR
T2 or T3 N1   M0	The cancer has grown 5 mm or more into the bile duct wall (T2 or T3) and has spread to 1 to 3 nearby lymph nodes (N1).   It has not spread to distant sites (M0).
IIIA	T1, T2, or T3 N2     M0	The cancer has grown to any depth into the bile duct wall (T1, T2, or T3) and to 4 or more nearby lymph nodes (N2).   It has not spread to distant sites (M0).
IIIB	T4       Any N         M0	The cancer is growing into nearby blood vessels (the celiac artery or its branches, the superior mesenteric artery, and/or the common hepatic artery) (T4).   The cancer may or may not have spread to nearby lymph nodes (Any N).   It has not spread to distant sites (M0).
IV	Any T   Any N       M1	The cancer has grown to any depth within the bile duct wall and may or may not be growing into nearby blood vessels (Any T).   It may or may not have spread to nearby lymph nodes (any N).   It has spread to distant organs such as the liver, lungs, or peritoneum (inner lining of the abdomen) (M1).

 

 *The T categories are described in the table above, except for:

• TX: Main tumor cannot be assessed due to lack of information.

The N categories are described in the table above, except for:

• NX: Nearby lymph nodes cannot be assessed due to lack of information.